Brian Regan is an American stand-up comedian. Brian Regan uses observational humor, which is also occasionally self-deprecating, and his performances are relatively "clean" as he refrains from off-color humor. Brian released his first CD, Brian Regan Live, in 1997. In 2004, Regan self-released a DVD of his performance at the Irvine Improv titled I Walked on the Moon.

In April 2007, Brian signed a deal with Comedy Central to star in two one-hour stand-up specials, release the specials on DVD, develop a show for the network, and headline a theater tour, “Brian Regan in Concert: A Comedy Central Live Event,” which began June 8, 2007. Brian Brian’s first one-hour special Standing Up debuted on Comedy Central on June 10, 2007. The special was recorded in April at The Barclay Theater in Irvine, CA and a DVD of the performance was released August 14, 2007. His second Comedy Central Special, entitled The Epitome of Hyperbole, premiered on September 6, 2008. A DVD of the performance was released September 9, 2008.